A fundamental challenge in modern science is to understand how the brain functions in health and disease. We are interested in understanding cellular and molecular mechanisms leading to chronic neurodegeneration after acute brain injuries  particularly brain trauma. To this end, we utilize   cutting-edge techniques including 3D imaging of entire cleared brains (recently developed by us), rabies virus tracing of neuronal networks, optogenetics and in vivo 2-photon imaging. Our overall goal is to determine molecular players that can be targeted (genetically or pharmacologically) to develop effective ways to halt chronic neurodegeneration after acute brain injuries.